Mapping the myelin bilayer with short-T2 MRI: Application to ex-vivo multiple sclerosis brain tissue
Emily Louise Baadsvik1, Markus Weiger1, Romain Froidevaux1, Wolfgang Faigle2, Benjamin Victor Ineichen3, and Klaas Paul Pruessmann1
1Institute for Biomedical Engineering, ETH Zurich and University of Zurich, Zurich, Switzerland, 2Neuroimmunology and MS Research Section, Neurology Clinic, University of Zurich, University Hospital Zurich, Zurich, Switzerland, 3Department of Neuroradiology, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland
Signal from the myelin bilayer can be captured using dedicated short-T2 imaging techniques, and analysis methods to isolate the contribution of the bilayer from other signal sources have been proposed. However, such analysis methods are often validated on samples in which the background water signal has been suppressed. Thus, it is unclear whether these techniques can successfully map myelin content in a clinical setting. Here, we apply and evaluate a previously proposed technique for myelin mapping to multiple sclerosis brain tissue without water suppression. We conclude that the quality of the myelin maps is comparable to that of water-suppressed samples.
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