Signal from the myelin bilayer can be captured using dedicated short-T2 imaging techniques, and analysis methods to isolate the contribution of the bilayer from other signal sources have been proposed. However, such analysis methods are often validated on samples in which the background water signal has been suppressed. Thus, it is unclear whether these techniques can successfully map myelin content in a clinical setting. Here, we apply and evaluate a previously proposed technique for myelin mapping to multiple sclerosis brain tissue without water suppression. We conclude that the quality of the myelin maps is comparable to that of water-suppressed samples.
This abstract and the presentation materials are available to members only; a login is required.