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Abstract #0202

Multiple sclerosis T2 lesion volume correlates weakly with myelin water fraction

Tigris S. Joseph1,2, Hanwen Liu2,3,4, Guojun Zhao4, Shannon H. Kolind1,2,4,5, Robert Carruthers4, Alice Schabas4, Ana-Luiza Sayao4, Virginia Devonshire4, Roger Tam5,6, G. R. Wayne Moore2,4,7, David K. B. Li4,5, Anthony Traboulsee4, Irene M. Vavasour2,5, and Cornelia Laule1,2,5,7
1Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 2International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada, 3Montreal Neurological Institute - Hospital, McGill University, Montreal, QC, Canada, 4Medicine, University of British Columbia, Vancouver, BC, Canada, 5Radiology, University of British Columbia, Vancouver, BC, Canada, 6School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada, 7Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

Synopsis

Multiple sclerosis (MS) lesion volume is commonly reported but is not pathologically specific or strongly associated with MS disability. Lesions are not necessarily demyelinated, which may be why lesion volume and disability are not strongly correlated. MS lesion volume was compared to Myelin Water Imaging (MWI) derived metrics related to myelin content (myelin water fraction) and inflammation (geometric mean T2) in MS normal appearing white matter and lesions. Weak correlations were observed between lesion volume and MWF, highlighting that the amount of lesional tissue does not reflect the degree of myelin damage within the brain.

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