Meeting Banner
Abstract #0213

Use of pCASL MRI to quantify Cerebral Blood Flow and Blood-Brain Barrier Permeability in Patients with Ischemic Stroke

Nikolaos Mouchtouris1, Mahdi Alizadeh2, Adam Flanders2, Chengyuan Wu1, Feroze Mohamed2, Reid Gooch1, Stavropoula Tjoumakaris1, and Pascal Jabbour1
1Neurosurgery, THOMAS JEFFERSON UNIVERSITY HOSPITAL, Philadelphia, PA, United States, 2Radiology, THOMAS JEFFERSON UNIVERSITY HOSPITAL, Philadelphia, PA, United States


In this pilot study, we apply diffusion-prepared pseudo-continuous arterial spin labeling (DP-pCASL) non-contrast MRI sequence to patients with anterior circulation ischemic strokes and determine the cerebral blood flow (CBF) and blood-brain barrier (BBB) permeability in the affected vascular territories. When comparing their imaging findings to 24 control hemispheres (12 healthy volunteers), we demonstrated that both the CBF and BBB of the affected MCA territory was significantly lower than the MCA territories in healthy volunteers. Additionally, the BBB permeability in the affected territory appears to be elevated in acute ischemic strokes but decreases in subacute strokes.

This abstract and the presentation materials are available to members only; a login is required.

Join Here