In this pilot study, we apply diffusion-prepared pseudo-continuous arterial spin labeling (DP-pCASL) non-contrast MRI sequence to patients with anterior circulation ischemic strokes and determine the cerebral blood flow (CBF) and blood-brain barrier (BBB) permeability in the affected vascular territories. When comparing their imaging findings to 24 control hemispheres (12 healthy volunteers), we demonstrated that both the CBF and BBB of the affected MCA territory was significantly lower than the MCA territories in healthy volunteers. Additionally, the BBB permeability in the affected territory appears to be elevated in acute ischemic strokes but decreases in subacute strokes.
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