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Abstract #0212

BBB water exchange rate and permeability mapping with multi-delay diffusion weighted pseudo-continuous arterial spin labeling

Xingfeng Shao1 and Danny JJ Wang1
1Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States


We proposed a new sequence which improves the SNR of diffusion weighted ASL signals, and simultaneously estimates kw, water extraction ratio (Ew) and PSw using a multi-delay approach with PLDs ranging from 1500 to 2700 msec. Whole brain average CBF = 67.8±6.7 ml/100g/min, kw = 103.7±16.6 min-1, Ew = 94.8±1.3% and PSw = 202.2±41.3 ml/100g/min. These results match the recent literatures on kw and PSw studies. Ew ~95% suggests two long PLDs of 2400 and 2700 msec are sufficient to allow complete water extraction.

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