Impact of 4D-flow MRI spatial resolution on quantitative hemodynamics in 3D-printed aortic dissection models with varying tear size
Judith Zimmermann1,2, Kathrin Bäumler1, Tyler E Cork1,3, Michael Loecher1,4, Alison L Marsden3,5, Dominik Fleischmann1, and Daniel B Ennis1,4
1Department of Radiology, Stanford University, Stanford, CA, United States, 2Department of Computer Science, Technical University of Munich, Garching, Germany, 3Department of Bioengineering, Stanford University, Stanford, CA, United States, 4Division of Radiology, Veterans Affairs Health Care System, Palo Alto, CA, United States, 5Department of Pediatrics, Stanford University, Stanford, CA, United States
Understanding flow dynamics in type-B aortic dissection (TBAD) is of high clinical interest to predict complications and individualize treatment. Here, we sought to evaluate 4D-flow MRI at high and low spatial image resolution, in comparison to high resolution, high signal-to-noise 2D phase contrast MRI. Further, we compare TBAD hemodynamics and flow alterations owing to changes in tear size. We leverage novel 3D printing technology to manufacture three compliant TBAD models with altered tear morphology and perform pressure- and flow-controlled MRI with an advanced in vitro flow setup.
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