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Abstract #0219

Longitudinal associations between 4D flow MRI intracranial pulsatility, white matter lesions, and perivascular space dilation across 5 years

Tomas Vikner1, Nina Karalija1,2, Anders Eklund1,2, Jan Malm3, Lars Nyberg1,2,4, and Anders Wåhlin1,2,5
1Department of Radiation Sciences, Umeå University, Umeå, Sweden, 2Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden, 3Department of Clinical Science, Neurosciences, Umeå University, Umeå, Sweden, 4Department of Integrative Medical Biology (IMB), Umeå University, Umeå, Sweden, 5Department of Applied Physics and Electronics, Umeå University, Umeå, Sweden


Small vessel disease (SVD) is associated with elevated vascular stiffness and pulsatility, but longitudinal studies are lacking. Using a 4D flow MRI approach sensitive to age-differences in pulsatility in large and small cerebral arteries, we evaluated 5-year changes in pulsatility in relation to changes in white matter lesions (WML) and perivascular spaces (PVS), radiological markers of SVD. Pulsatility change correlated with WML and PVS volume change, but pulsatility at baseline did not predict WML and PVS progression. However, WML and PVS volumes at baseline predicted 5-year pulsatility change, suggesting that microvascular dysfunction associated with SVD accelerates pulsatility increases.

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