Abstract #0219

Longitudinal associations between 4D flow MRI intracranial pulsatility, white matter lesions, and perivascular space dilation across 5 years

Tomas Vikner¹, Nina Karalija^1,2, Anders Eklund^1,2, Jan Malm³, Lars Nyberg^1,2,4, and Anders Wåhlin^1,2,5

¹Department of Radiation Sciences, Umeå University, Umeå, Sweden, ²Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden, ³Department of Clinical Science, Neurosciences, Umeå University, Umeå, Sweden, ⁴Department of Integrative Medical Biology (IMB), Umeå University, Umeå, Sweden, ⁵Department of Applied Physics and Electronics, Umeå University, Umeå, Sweden

Synopsis

Small vessel disease (SVD) is associated with elevated vascular stiffness and pulsatility, but longitudinal studies are lacking. Using a 4D flow MRI approach sensitive to age-differences in pulsatility in large and small cerebral arteries, we evaluated 5-year changes in pulsatility in relation to changes in white matter lesions (WML) and perivascular spaces (PVS), radiological markers of SVD. Pulsatility change correlated with WML and PVS volume change, but pulsatility at baseline did not predict WML and PVS progression. However, WML and PVS volumes at baseline predicted 5-year pulsatility change, suggesting that microvascular dysfunction associated with SVD accelerates pulsatility increases.

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