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Abstract #0231

Y-90 treatment lung shunting prediction of hepatocellular cancer using DCE MRI with kinetic modeling and quantitative transport mapping

Qihao Zhang1, Kyungmouk Steve Lee2, Thanh Nguyen3, Pascal Spincemaille2, and Yi Wang2
1Cornell University, Ithaca, NY, NY, United States, 2Weill Cornell Medical College, New York, NY, United States, 3Cornell University, New York, NY, United States


Trans-arterial radioembolization with yttrium-90 microspheres (TARE with Y90) is a treatment for patients with liver cancers, but requires the evaluation of lung shunting fraction (LSF). Currently, LSF is estimated using a separate invasive “dry-run” with a transient radioactive Technetium-99m macroaggregated albumin (Tc-99m-MAA) that doubles the cost and risk of TARE. This study proposes to predict LSF from dynamic contrast enhanced MRI (DCE MRI) and perfusion quantification. Our preliminary data demonstrated that it is feasible to estimate LSF as measured by Tc-99m-MAA from noninvasive DCE MRI using quantitative transport mapping (QTM) velocity.

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