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Abstract #0232

Distortion- and ghosting-free high b-value ex vivo human brain diffusion MRI achieved with spatiotemporal magnetic field monitoring

Gabriel Ramos-Llorden1, Daniel Park1, Christian Mirkes2, Cameron M. Cushing3, Paul Weavers3, Hong-Hsi Lee1, Qiyuan Tian1, Alina Scholz4, Boris Keil4, Berkin Bilgic1,5, Anastasia Yendiki1, Thomas Witzel6, and Susie Y. Huang1,5
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, 2Skope Magnetic Resonance Technologies AG, Zurich, Switzerland, 3Skope Magnetic Resonance Inc, Lake Mills, WI, United States, 4Institute of Medical Physics and Radiation Protection, Giessen, Germany, 5Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States, 6Q Bio Inc,, San Carlos, MA, United States


Whole brain ex vivo diffusion MRI needs high b-value encoding to compensate for the reduced diffusivity, requiring human brain scanners with ultra-strong diffusion gradients. At that regime, eddy currents become too severe, to the point image distortions and ghosting artifacts cannot be enough mitigated with conventional image reconstruction and post-processing approaches. On a 3T Connectom scanner , we demonstrate the importance of spatiotemporal field monitoring to measure and model eddy currents. When Fourier reconstruction is informed with the unwanted spatiotemporal evolution of the phase, distortion- and ghosting-free high-resolution DW images can be achieved.

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