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Abstract #0255

Investigating exchange, structural disorder and restriction in Gray Matter via water and metabolites diffusivity and kurtosis time-dependence

Eloïse MOUGEL1, Julien Valette1, and Marco Palombo2,3,4
1Université Paris-Saclay, Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), Centre National de la Recherche Scientifique(CNRS), Molecular Imaging Research Center (MIRCen), Laboratoire des Maladies Neurodégénératives, Fontenay aux Roses, France, 2Centre for Medical Image Computing (CMIC), Department of Computer Science, University College London, London, United Kingdom, 3Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, 4School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom


This work reports first-time measurements of the time-dependent diffusivity and kurtosis of both water and metabolites in vivo in the mouse gray matter (GM). Our aim is to exploit the complementary information provided by the diffusion of water and intracellular metabolites to investigate and potentially disentangle the role of exchange, structural disorder and restriction in GM. Our results show evidence that water diffusion-time dependence in GM is mostly driven by 1D short-range disorder, potentially alongside exchange. Conversely, metabolites’ diffusion-time dependence is exclusively driven by cellular restrictions, paving a new way to quantify noninvasively microstructural restrictions in GM.

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