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Abstract #0263

The relation between brain anatomy, functional connectivity, and emotional behavior in 3- and 9-month old infants

Layla Banihashemi1, Vanessa Jean Schmithorst1, Michele A Bertocci1, Alyssa Samolyk1, Joao Santos1, Amelia Versace1, Megan Taylor1, Gabrielle English1, Jessie Northrup1, Vincent Lee1, Richelle Stiffler1, Harris Aslam1, Ashok Panigrahy1, Alison Hipwell1, and Mary Phillips1
1University of Pittsburgh, Pittsburgh, PA, United States


Uncinate fasciculus, forceps minor, and cingulum bundle volumes measured in infants at 3 months of age via DWI tractography were found to predict infant emotionality at 3 months and 9 months of age. These relations were found to be mediated and/or suppressed by functional connectivity from the orbitofrontal cortex, dorsolateral prefrontal cortex, and posterior default mode. Therefore, modulating connectivity among regions in the default mode, central executive, and salience networks might be promising future approaches for interventions to maintain infant emotionality and reduce risk of future psychopathology later in childhood and adolescence.

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