Uncinate fasciculus, forceps minor, and cingulum bundle volumes measured in infants at 3 months of age via DWI tractography were found to predict infant emotionality at 3 months and 9 months of age. These relations were found to be mediated and/or suppressed by functional connectivity from the orbitofrontal cortex, dorsolateral prefrontal cortex, and posterior default mode. Therefore, modulating connectivity among regions in the default mode, central executive, and salience networks might be promising future approaches for interventions to maintain infant emotionality and reduce risk of future psychopathology later in childhood and adolescence.
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