Despite previous attempts to localize the human homologues of the medial (MEC) and lateral entorhinal cortex (LEC) using fMRI and DTI separately, there are still uncertainties related to the choice of imaging modality and seed regions used. In this study, we investigated both structural connectivity from DTI and functional connectivity from fMRI between the EC and associated brain regions. Differential EC connectivity to these regions was then used to predict the locations of the human homologues of MEC and LEC. Our results from both DTI and fMRI showed a qualitatively similar subdivision into posteromedial and anterolateral EC, supporting previous studies.
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