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Abstract #0264

Investigating structural and functional connectivity of human entorhinal subregions using DTI and fMRI

Ingrid Framås Syversen1,2, Daniel Reznik3, Tobias Navarro Schröder1, and Christian F. Doeller1,3,4
1Kavli Institute for Systems Neuroscience, NTNU - Norwegian University of Science and Technology, Trondheim, Norway, 2Department of Diagnostic Imaging, Akershus University Hospital, Lørenskog, Norway, 3Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 4Institute of Psychology, Leipzig University, Leipzig, Germany


Despite previous attempts to localize the human homologues of the medial (MEC) and lateral entorhinal cortex (LEC) using fMRI and DTI separately, there are still uncertainties related to the choice of imaging modality and seed regions used. In this study, we investigated both structural connectivity from DTI and functional connectivity from fMRI between the EC and associated brain regions. Differential EC connectivity to these regions was then used to predict the locations of the human homologues of MEC and LEC. Our results from both DTI and fMRI showed a qualitatively similar subdivision into posteromedial and anterolateral EC, supporting previous studies.

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