Abstract #0265

Type 2 diabetes mellitus and obesity are associated with altered T2* and resting-state brain activity: a UK Biobank study

Guocheng Jiang^1,2, Walter Swardfager^2,3, Abdullah Al-Ozairi⁴, Ebaa Al-Ozairi ⁵, Sandra E Black ^2,6, and Bradley J MacIntosh^1,2

¹Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Hurvitz Brain Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ³Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada, ⁴Department of Psychiatry, Kuwait University, Kuwait City, Kuwait, ⁵Dasman Diabetes Institute, Kuwait City, Kuwait, ⁶Department of Medicine, University of Toronto, Toronto, ON, Canada

Synopsis

T2*-weighted image is a versatile and common MR imaging readout. We studied anatomical and functional brain features in three groups: Type 2 diabetes mellitus (T2DM), obese, and healthy adults. We observed that T2DM and obese adults are associated with lower regional T2* relative to healthy adults. We further found that an adverse lipid profile in obese adults was associated with decreased regional brain intrinsic activity. This work helps to characterize how T2DM and obesity affects brain using susceptibility-weighted and resting-state functional MRI approaches.

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