Type 2 diabetes mellitus and obesity are associated with altered T2* and resting-state brain activity: a UK Biobank study
Guocheng Jiang1,2, Walter Swardfager2,3, Abdullah Al-Ozairi4, Ebaa Al-Ozairi 5, Sandra E Black 2,6, and Bradley J MacIntosh1,2
1Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Hurvitz Brain Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 3Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada, 4Department of Psychiatry, Kuwait University, Kuwait City, Kuwait, 5Dasman Diabetes Institute, Kuwait City, Kuwait, 6Department of Medicine, University of Toronto, Toronto, ON, Canada
T2*-weighted image is a versatile and common MR imaging readout. We studied anatomical and functional brain features in three groups: Type 2 diabetes mellitus (T2DM), obese, and healthy adults. We observed that T2DM and obese adults are associated with lower regional T2* relative to healthy adults. We further found that an adverse lipid profile in obese adults was associated with decreased regional brain intrinsic activity. This work helps to characterize how T2DM and obesity affects brain using susceptibility-weighted and resting-state functional MRI approaches.
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