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Abstract #0268

Alterations in intrinsic functional networks in squirrel monkey brain produced by dorsal column lesion of spinal cord using resting state fMRI

Anirban Sengupta1, Arabinda Mishra1, Feng Wang1, Li Min Chen1, and John C Gore1
1Vanderbilt University Medical Center, Nashville, TN, United States


The goal was to study how intrinsic functional networks within squirrel monkey brain undergo changes in connectivity after a dorsal column lesion (DCL) of the spinal cord. We used independent component analysis (ICA) to decompose whole brain fMRI data into spatially independent functional networks. Thirteen networks were identified, many of which resemble networks from human and macaque brain studies. Inter-network connectivity was computed before and after DCL of the cervical spinal cord. Changes in inter-network connectivity were not restricted to sensorimotor areas but spread over other cortical areas. Also, one of the connectivity increased significantly, possibly indicating compensation post lesion

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