Cardiac MR elastography (MRE) has the potential to noninvasively characterize the underlying pathophysiology in heart failure with preserved ejection fraction based on abnormal stiffness values. However, the need for synchronizing MRE with cardiac motion, breathing and harmonic vibrations continues to be a challenge. We have developed a single-shot, spin-echo cardiac MRE sequence, which continuously acquires wave images at multiple frequencies with retrospective gating of wave phases relative to the cardiac phase to cover the propagation of shear waves over the full cardiac cycle. Our preliminary data show the dispersion of myocardial stiffness over frequency in systole and diastole.
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