Multifrequency MR elastography for time-resolved shear wave speed quantification of the in-vivo human heart.
Matthias Anders1, Carsten Warmuth1, Heiko Tzschätzsch1, Helge Herthum1, Katja Degenhardt2, Sebastian Schmitter2, Jeanette Schulz-Menger1,3,4, Jürgen Braun1, and Ingolf Sack1
1Charité Universitätsmedizin Berlin, Berlin, Germany, 2Physikalisch-Technische Bundesanstalt(PTB), Braunschweig and Berlin, Berlin, Germany, 3Experimentaland Clinical Research Center (ECRC), DZHK partner site Berlin, Berlin, Germany, 4HELIOS Klinikum Berlin Buch, Berlin, Germany
Cardiac MR elastography (MRE) has the potential to noninvasively characterize the underlying pathophysiology in heart failure with preserved ejection fraction based on abnormal stiffness values. However, the need for synchronizing MRE with cardiac motion, breathing and harmonic vibrations continues to be a challenge. We have developed a single-shot, spin-echo cardiac MRE sequence, which continuously acquires wave images at multiple frequencies with retrospective gating of wave phases relative to the cardiac phase to cover the propagation of shear waves over the full cardiac cycle. Our preliminary data show the dispersion of myocardial stiffness over frequency in systole and diastole.
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