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Abstract #0278

Increased Pulsatility Index of Perforating Arteries as Novel 7T Marker in Sporadic Cerebral Small Vessel Disease – Results of ZOOM@SVDs Study.

Stanley D.T. Pham1, Hilde van den Brink2, Tine Arts1, Jeroen C.W. Siero1, Jeroen Hendrikse1, Jaco J.M. Zwanenburg1, and Geert Jan Biessels2
1Radiology, UMC Utrecht, Utrecht, Netherlands, 2Neurology and Neurosurgery, UMC Utrecht, Utrecht, Netherlands


We assessed blood-flow velocity measurements on 7T MRI as a potential disease marker for cerebral small vessel disease (SVD). Two-dimensional phase-contrast velocity measurements were performed in perforating arteries of the basal ganglia (BG) and white matter of the centrum semiovale (CSO) in patients with sporadic SVD and age- and sex-matched controls. Pulsatility index (PI) was significantly higher in the BG, in patients (0.45 [0.41–0.49] vs. 0.36 [0.30–0.41] in controls) (p=0.02). In the CSO, similar number of vessels, mean velocity, and PI were observed between patients and controls. BG pulsatility could be a potential marker for SVD.

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