Maintenance of cerebral tissue homeostasis is particularly sensitive to deficits in cerebral blood flow (CBF) and concomitant hypoxia and hypoglycemia. However, little work has been conducted to investigate the potential association between deficits in CBF and deterioration of brain microstructure, especially in normative aging. The results of our analysis, conducted on a large cohort of cognitively unimpaired adults, of the association between CBF and several MRI metrics of cerebral microstructural integrity, indicate that low CBF values correspond to low tissue integrity. These results provide further evidence of the intimate relationship between neurovascular physiology and brain integrity throughout normative aging.
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