Meeting Banner
Abstract #0282

Medullary vein architecture modulates the white matter BOLD CVR response to CO2: observations from high-resolution T2* weighted imaging at 7T

Alex A Bhogal1
1UMC Utrecht, Utrecht, Netherlands


Brain stress testing using blood oxygenation level-dependent (BOLD) MRI to evaluate changes in cerebrovascular reactivity (CVR) is of growing interest for evaluating white matter integrity. However, even under healthy conditions, the white matter BOLD-CVR response differs notably from that observed in the gray matter. The confluence of arterial hemodynamics and BOLD signal characteristics weighted by venous architecture unrelated to smooth-muscle mediated dilation/contraction play a significant role in defining the WM BOLD-signal response to hypercapnia. This caveat should be taken into account when attributing disease mechanisms and/or progression to presumed impaired WM BOLD-CVR.

This abstract and the presentation materials are available to members only; a login is required.

Join Here