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Abstract #0287

Glucose versus fructose metabolism in the liver measured with deuterium metabolic imaging

Arjan D. Hendriks1, Andor Veltien2, Ingmar J. Voogt3, Arend Heerschap2, Tom W.J. Scheenen2, and Jeanine J. Prompers1
1Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Medical Imaging (Radiology), Radboud University Medical Center, Nijmegen, Netherlands, 3WaveTronica B.V., Utrecht, Netherlands


The worldwide increase in sugar consumption is a major health concern. The contribution of fructose to the epidemic of metabolic disorders is controversial. This study investigated differences between glucose and fructose metabolism in the liver using dynamic deuterium metabolic imaging (DMI). Deuterium signal time curves after bolus injection and slow infusion were successfully acquired and showed different patterns. It was found that the peak concentration and conversion of deuterated glucose was different from that of fructose, indicating faster turnover of the latter. Overall, these methods could potentially lead to better understanding of healthy liver metabolism and aberrations in metabolic diseases.

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