This work fuses manual segmentation of T2/FLAIR hyperintensity regions using 3D Slicer with multivoxel magnetic resonance spectroscopy (MRSI), which profiles neurochemical concentrations in a wide area of the brain. The utility of MRSI is demonstrated in the mapping of metabolites including 2HG, N-acetyl aspartate, myoinositol, glutamate plus glutamine, lactate, and choline in the region of interest. Voxel fractions of hyperintensity were correlated to metabolites, and metabolite-to-creatine ratio intercepts were used to compare hyperintense with healthy tissue.
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