Telomerase reverse transcriptase (TERT) expression results from TERT promoter mutations and is a hallmark of cancer. GABPB1, its upstream transcriptional factor, was recently identified as a promising tumor-specific therapeutic target. However, imaging methods that can detect TERT expression and its inhibition with emerging GABPB1-based therapeutics are limited. Here, we demonstrate that the combination of 1H-MRS and hyperpolarized 13C-MRS of [1-13C]pyruvate allow detection of TERT modulation in TERT-expressing GBM cells and in vivo tumors. These findings could be translated to the clinic and thus improve the monitoring and personalized treatment of GBM.
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