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Abstract #0285

MRS-Detectable Metabolic Biomarkers of TERT positive Glioblastoma

Noriaki Minami1, Donghyun Hong1, Nicholas Stevers2, Carter J Barger2, Georgios Batsios1, Anne Marie Gillespie1, Joseph F Costello2, Pavithra Viswanath1, and Sabrina M Ronen1
1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2Department of Neurological Surgery, UCSF, San Francisco, CA, United States


Telomerase reverse transcriptase (TERT) expression results from TERT promoter mutations and is a hallmark of cancer. GABPB1, its upstream transcriptional factor, was recently identified as a promising tumor-specific therapeutic target. However, imaging methods that can detect TERT expression and its inhibition with emerging GABPB1-based therapeutics are limited. Here, we demonstrate that the combination of 1H-MRS and hyperpolarized 13C-MRS of [1-13C]pyruvate allow detection of TERT modulation in TERT-expressing GBM cells and in vivo tumors. These findings could be translated to the clinic and thus improve the monitoring and personalized treatment of GBM.

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