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Abstract #0289

Imaging hypoxia in murine oral cavity squamous cell carcinomas with oxygen-enhanced MRI

Upasana Roy1, Elise Y. Lepicard1, Jessica K.R. Boult1, Carol Box1, Kevin J. Harrington1, James P.B. O’Connor1, Yann Jamin1, and Simon P. Robinson1
1Division of Radiotherapy and Imaging, The Institute of Cancer Research, Sutton, United Kingdom


Oxygen-enhanced (OE)-MRI was used to map and quantify hypoxia (pOxyR) in two murine models of oral cavity squamous cell carcinoma, a tumour type in which hypoxia adversely affects patient prognosis. OE-MRI relies on quantifying changes in the longitudinal MRI relaxation rate R1 induced by excess paramagnetic oxygen molecules dissolved in blood plasma and interstitial fluid with inhalation of oxygen. When combined with susceptibility-contrast MRI for determination of fractional blood volume and diffusion-weighted MRI to assess cellularity, OE-MRI enables an assessment of the spatial distribution and extent of tumour hypoxia, patent vasculature and necrosis.

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