Abstract #0290
First in-human technique translation of OE-MRI for hypoxia imaging onto an MR Linac system in patients with head and neck cancer
Michael J Dubec1,2, Anubhav Datta1,3, Ross A Little1, Abigael Clough4, David L Buckley2,5, Christina Hague6, Damien McHugh1,2, Michael Berks1, Susan Cheung1, Amal Salah7, David Higgins8, Cynthia L Eccles1,4, Robert Bristow1,6, Josephine H Naish9,10, Julian C Matthews11, Peter Hoskin1,6,12, Marcel van Herk1, Geoff JM Parker10,13, Ananya Choudhury1,6, Andrew McPartlin6, and James PB O'Connor1,3,14
1Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom, 2Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, United Kingdom, 3Radiology, The Christie NHS Foundation Trust, Manchester, United Kingdom, 4Radiotherapy, The Christie NHS Foundation Trust, Manchester, United Kingdom, 5Biomedical Imaging, University of Leeds, Leeds, United Kingdom, 6Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom, 7Proton Beam Therapy, The Christie NHS Foundation Trust, Manchester, United Kingdom, 8Philips, Manchester, United Kingdom, 9MCMR, University of Manchester NHS Foundation Trust, Manchester, United Kingdom, 10Bioxydyn Ltd, Manchester, United Kingdom, 11Neuroscience and Experimental Psychology, University of Manchester, Manchester, United Kingdom, 12Radiotherapy, Mount Vernon, London, United Kingdom, 13Centre for Medical Image Computing, Unversity College London, London, United Kingdom, 14Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom
Synopsis
Tumour hypoxia is associated with poor treatment outcome, tumour progression and treatment resistance. Oxygen-enhanced (OE)-MRI has shown promise as a non-invasive method for mapping and quantifying hypoxia. We demonstrate, for the first time, the application of the OE-MRI technique in patients with head and neck carcinoma to monitor changes in hypoxia due to treatment, and translate the technique onto an MR Linac system, demonstrating feasibility in a first-in-human study.
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