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Abstract #0291

Cortical layer-specific neurochemical profiles in the in-vivo mouse brain

Alireza Abaei1, Dinesh K Deelchand 2, Francesco Roselli 3, and Volker Rasche 1
1Core Facility Small Animal Imaging (CF-SANI), University of Ulm, Ulm, Germany, 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 3German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany


The goal of this study was to demonstrate the feasibility to detect neurochemical differences in sub-cortical domains of the murine brain, namely upper (I-IIII) and deep (V-VI) layers. To achieve sub-microliter voxel prescription in these layers, an ultra-high field of 11.7T was used along with the single-voxel LASER sequence. Results show significantly higher taurine (13%) and phosphatidylethanolamine (36%) concentrations in the superficial cortex region compared to the deep layer, in good agreement with cellular composition of these two regions.

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