The goal of this study was to demonstrate the feasibility to detect neurochemical differences in sub-cortical domains of the murine brain, namely upper (I-IIII) and deep (V-VI) layers. To achieve sub-microliter voxel prescription in these layers, an ultra-high field of 11.7T was used along with the single-voxel LASER sequence. Results show significantly higher taurine (13%) and phosphatidylethanolamine (36%) concentrations in the superficial cortex region compared to the deep layer, in good agreement with cellular composition of these two regions.
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