Abstract #0291

Cortical layer-specific neurochemical profiles in the in-vivo mouse brain

Alireza Abaei¹, Dinesh K Deelchand ², Francesco Roselli ³, and Volker Rasche ¹

¹Core Facility Small Animal Imaging (CF-SANI), University of Ulm, Ulm, Germany, ²Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ³German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany

Synopsis

The goal of this study was to demonstrate the feasibility to detect neurochemical differences in sub-cortical domains of the murine brain, namely upper (I-IIII) and deep (V-VI) layers. To achieve sub-microliter voxel prescription in these layers, an ultra-high field of 11.7T was used along with the single-voxel LASER sequence. Results show significantly higher taurine (13%) and phosphatidylethanolamine (36%) concentrations in the superficial cortex region compared to the deep layer, in good agreement with cellular composition of these two regions.

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