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Abstract #0292

An Alternative to WEX: T1-Independent Exchange Rate Quantification using Phase Sensitive Water Exchange Spectroscopy

Nils Marc Joel Plaehn1, Simon Mayer1,2, Petra Albertová1, Peter Michael Jakob1, and Fabian Tobias Gutjahr1
1Experimental Physics 5, University of Würzburg, Würzburg, Germany, 2Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben, Germany


Water Exchange Spectroscopy (WEX) is one of the most widely used approaches to assess the exchange rate of labile protons from a solute to water. In this work, we propose as an versatile alternative “Phase Sensitive WEX” (PS-WEX), which uses an additional RF-pulse and a fixed mixing-time delay. By exploiting the phase sensitivity of the PS-WEX pathway the dynamic range can be increased and the T1-dependence of the signal is completely reduced. This is demonstrated in simulations and phantom measurements. The fixed mixing-time reduces the influence of the T1-decay on the signal curve leading to improved fit quality.

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