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Abstract #0293

Clinical Applicability of SLOW-editing compared to MEGA-editing for the Evaluation of the IDH-mutation Status in Glioma Patients at 7T

Guodong Weng1,2, Johannes Slotboom1,2, and Piotr Radojewski1,2
1Institute for Diagnostic and Interventional Neuroradiology, Support Center for Advanced Neuroimaging (SCAN), University of Bern, Bern, Switzerland, 2Translational Imaging Center, sitem-insel AG, Bern, Switzerland


Purpose: comparison of SLOW-editing and MEGA-editing for detection of 2HG in glioma-suspected patients at 7T.

Methods: EPSI-based B0/B0+ robust SLOW-editing and semiLASER-SVS/CSI-based MEGA-editing were applied in 10 patients. The edited 2HG signal at 4.01 ppm aimed to be detected with TE = 68 – 75 ms.

Results: 8 of 9 patients were identified successfully using SLOW-editing which has a higher spectral quality and success rate compared to MEGA-semiLASER. semiLASER-SVS/CSI-based MEGA-editing showed strong ghosting artifacts around 4.01ppm making 2HG-identification impossible.

Conclusions: in vivo 2HG-editing can be performed using SLOW-EPSI within 10 minutes measurement time and is the preferrable method at UHF.

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