Purpose: comparison of SLOW-editing and MEGA-editing for detection of 2HG in glioma-suspected patients at 7T.
Methods: EPSI-based B0/B0+ robust SLOW-editing and semiLASER-SVS/CSI-based MEGA-editing were applied in 10 patients. The edited 2HG signal at 4.01 ppm aimed to be detected with TE = 68 – 75 ms.
Results: 8 of 9 patients were identified successfully using SLOW-editing which has a higher spectral quality and success rate compared to MEGA-semiLASER. semiLASER-SVS/CSI-based MEGA-editing showed strong ghosting artifacts around 4.01ppm making 2HG-identification impossible.
Conclusions: in vivo 2HG-editing can be performed using SLOW-EPSI within 10 minutes measurement time and is the preferrable method at UHF.