Abstract #0293

Clinical Applicability of SLOW-editing compared to MEGA-editing for the Evaluation of the IDH-mutation Status in Glioma Patients at 7T

Guodong Weng^1,2, Johannes Slotboom^1,2, and Piotr Radojewski^1,2

¹Institute for Diagnostic and Interventional Neuroradiology, Support Center for Advanced Neuroimaging (SCAN), University of Bern, Bern, Switzerland, ²Translational Imaging Center, sitem-insel AG, Bern, Switzerland

Synopsis

Purpose: comparison of SLOW-editing and MEGA-editing for detection of 2HG in glioma-suspected patients at 7T.

Methods: EPSI-based B₀/B₀⁺ robust SLOW-editing and semiLASER-SVS/CSI-based MEGA-editing were applied in 10 patients. The edited 2HG signal at 4.01 ppm aimed to be detected with TE = 68 – 75 ms.

Results: 8 of 9 patients were identified successfully using SLOW-editing which has a higher spectral quality and success rate compared to MEGA-semiLASER. semiLASER-SVS/CSI-based MEGA-editing showed strong ghosting artifacts around 4.01ppm making 2HG-identification impossible.

Conclusions: in vivo 2HG-editing can be performed using SLOW-EPSI within 10 minutes measurement time and is the preferrable method at UHF.

This abstract and the presentation materials are available to members only; a login is required.

Join Here