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Abstract #0294

Fast high-resolution metabolite mapping on a preclinical 14.1T scanner using 1H-FID-MRSI

Dunja Simicic1,2,3, Brayan Alves1,2, Jessie Julie Mosso1,2,3, Thanh Phong Lê3,4, Ruud B. van Heeswijk5, Jana Starcukova6, Antoine Klauser1,7, Bernhard Strasser8, Wolfgang Bogner8, and Cristina Cudalbu1,2
1CIBM Center for Biomedical Imaging, Lausanne, Switzerland, 2Animal Imaging and Technology, EPFL, Lausanne, Switzerland, 3Laboratory of Functional and Metabolic Imaging, EPFL, Lausanne, Switzerland, 4HES-SO University of Applied Sciences and Arts Western Switzerland, Geneva School of Health Sciences, Geneva, Switzerland, 5Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 6Institute of Scientific Instruments, Czech Academy of Sciences, Brno, Czech Republic, 7Department of radiology and medical informatics, University of Geneva, Geneva, Switzerland, 8Department of Radiology, Medical University Vienna, MR Center of Excellence, Vienna, Austria


1H-MRSI enables a simultaneous acquisition of MR-spectra from multiple spatial locations inside the brain. While 1H-MRSI is increasingly used in the human brain, its implementation in preclinical setting is limited because of the smaller size of rodent brain. At UHF for humans, 1H-FID-MRSI acquisitions are increasingly used (T2 and J-evolution minimization, increased SNR). We present the first implementation of fast 1H-FID-MRSI in the rat brain at 14.1T and exploit its potential for an increased brain coverage, reliable and accurate quantification results and metabolic maps. Our results set the grounds for a wider application of 1H-FID-MRSI in the preclinical setting.

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