We developed a multi-echo sequence to detect phosphomonoesters (PME) and phosphodiesters (PDE), aiming for high signal-to-noise and T2-contrast to noise ratio per unit of time, with the constraint of a maximum available B1 of ~15μT. In line with MRI, the candidates were multi-echo MRSI with 180° pulses (full refocusing) and fast spin echo (FSE) with modulated variable flip angles. Multi-echo MRSI resulted in higher SNR at the same SAR level compared to a FSE with modulated refocusing flip angles. Using 9 dual-band echo pulses improved the SNR for PDE and PME more than two-fold compared to the FID signal alone.
This abstract and the presentation materials are available to members only; a login is required.