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Abstract #0296

31P multi-echo imaging with low B1+ dual-band refocusing pulses

Zahra Shams1, Wybe J.M. van der Kemp1, Evita C. Wiegers1, Jacobus J.M. Zwanenburg1, Jannie P. Wijnen1, and Dennis W.J. Klomp1
1Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands


We developed a multi-echo sequence to detect phosphomonoesters (PME) and phosphodiesters (PDE), aiming for high signal-to-noise and T2-contrast to noise ratio per unit of time, with the constraint of a maximum available B1 of ~15μT. In line with MRI, the candidates were multi-echo MRSI with 180° pulses (full refocusing) and fast spin echo (FSE) with modulated variable flip angles. Multi-echo MRSI resulted in higher SNR at the same SAR level compared to a FSE with modulated refocusing flip angles. Using 9 dual-band echo pulses improved the SNR for PDE and PME more than two-fold compared to the FID signal alone.

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