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Abstract #0297

Super-fast and accurate estimation of relaxation and chemical exchange rate using 31P-MT-MR fingerprinting at 7T in the human brain

Mark Stephan Widmaier1,2, Song-I Lim1,2, and Lijing Xin1,3
1CIBM Center for Biomedical Imaging, Lausanne, Switzerland, 2Laboratory for Functional and Metabolic Imaging, EPFL, Lausanne, Switzerland, 3Animal Imaging and Technology, EPFL, Lausanne, Switzerland


In this abstract, we introduce 31P-MT-MRF, using a SAR efficient magnetization transfer (MT) approach. We extended the magnet resonance fingerprinting (MRF) framework to overcome obstacles of in vivo human brain 31P measurements. This abstract reports the reproducibility and robustness of 31P-MT-MRF estimations of the relaxation parameters of y-ATP and PCr as well as the chemical exchange rate kCK on healthy volunteers in vivo in human brain at 7T. We were able to demonstrate that our method is 3 times faster as state-of-the-art MT methods [6] and estimates are bias free enabling ultra-fast kCK measurement in 2:15 min scan time.

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