Abstract #0307

Changes in occipital GABA, glutamate/glutamine concentrations and cerebral oxygen metabolism in response to visual stimulation

Kimberly L Chan¹, Hanzhang Lu², Zixuan Lin², Anke Henning^3,4, and Binu P Thomas¹

¹Advanced Imaging Research Center, The University of Texas Southwestern, Dallas, TX, United States, ²Johns Hopkins University, Baltimore, MD, United States, ³The University of Texas Southwestern, Dallas, TX, United States, ⁴Max Planck Institute for Biological Cybernetics, Tübingen, Germany

Synopsis

The relationship between brain’s GABA and glutamate/glutamine (Glx) concentrations measured by 1H MRS, hemodynamic response, neural signaling, and behavior is poorly understood. Here, the relationship between MRS-detectable GABA and Glx signals and MR hemodynamic contrasts during visual stimulation were examined. It was observed that changes in GABA+ and Glx were positively correlated with the BOLD response and negatively correlated with their levels at rest. Additionally, task GABA+ concentrations were negatively correlated with cerebral metabolic rate of oxygen (CMRO2). Together, these results suggest shifts in the inhibitory/excitatory balance and metabolism to maintain homeostasis in the brain.

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