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Abstract #0307

Changes in occipital GABA, glutamate/glutamine concentrations and cerebral oxygen metabolism in response to visual stimulation

Kimberly L Chan1, Hanzhang Lu2, Zixuan Lin2, Anke Henning3,4, and Binu P Thomas1
1Advanced Imaging Research Center, The University of Texas Southwestern, Dallas, TX, United States, 2Johns Hopkins University, Baltimore, MD, United States, 3The University of Texas Southwestern, Dallas, TX, United States, 4Max Planck Institute for Biological Cybernetics, Tübingen, Germany


The relationship between brain’s GABA and glutamate/glutamine (Glx) concentrations measured by 1H MRS, hemodynamic response, neural signaling, and behavior is poorly understood. Here, the relationship between MRS-detectable GABA and Glx signals and MR hemodynamic contrasts during visual stimulation were examined. It was observed that changes in GABA+ and Glx were positively correlated with the BOLD response and negatively correlated with their levels at rest. Additionally, task GABA+ concentrations were negatively correlated with cerebral metabolic rate of oxygen (CMRO2). Together, these results suggest shifts in the inhibitory/excitatory balance and metabolism to maintain homeostasis in the brain.

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