Being more specific to cellular microstructure than water diffusion, diffusion-weighted spectroscopic imaging (DW-MRSI) is a powerful tool for measuring disorders in cortical gray matter. Nevertheless, measurement in the cortex is difficult due to its proximity to the skull. We propose a selective DW-MRSI sequence, which avoids lipid contamination and measures the signal of metabolites even in the cortex. We performed an in vivo acquisition with this sequence and were able to measure an apparent diffusion coefficient over an entire brain slab.
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