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Abstract #0309

Dynamic fitting of functional MRS, diffusion weighted MRS, and edited MRS using a single interface

William T Clarke1, Clémence Ligneul1, Michiel Cottaar1, and Saad Jbabdi1
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom


Dynamic magnetic resonance spectroscopy acquires multiple spectra under changing experimental conditions. Examples include editing, functional MRS, and diffusion weighted MRS. In this work we introduce a new tool that allows direct fitting of a dynamic signal model to multiple spectra simultaneously. Incorporation of a dynamic model into multi-spectra fitting reduces the number of parameters to be estimated from noisy data, reducing overall uncertainty.

The tool is demonstrated on simulated and multi-subject in vivo datasets, highlighting the high flexibility of the tool, which is open source and available as part of the FSL-MRS toolbox.

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