Abstract #0310
Dynamic 13C MRS using 13C/1H Multichannel Coil as an Alternative to Imaging for Hyperpolarized Pyruvate Brain Studies
Junjie Ma1, Marco C. Pinho1,2, Crystal E. Harrison1, Jun Chen1, Galen D. Reed3, Albert P. Chen3, A. Dean Sherry1,4, Craig R. Malloy1,2,5, Christopher J. Madden6, and Jae Mo Park1,2,7
1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 3GE Healthcare, Dallas, TX, United States, 4Biochemistry and Chemical Biology, UT Dallas, Richardson, TX, United States, 5Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States, 6Neurological Surgery, UT Southwestern Medical Center, Dallas, TX, United States, 7Electrical and Computer Engineering, UT Dallas, Richardson, TX, United States
Synopsis
This study demonstrates that time-resolved 13C MR spectroscopy with the multichannel 13C/1H RF coils can be performed as an alternative to imaging for assessing pyruvate metabolism using hyperpolarized [1-13C]pyruvate in the human brain.
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