Multi-Echo Single-Shot (MESS) spectroscopy is tested in-vivo aiming at simultaneous determination of metabolite content and T2 times through simultaneous multi-parametric model fitting of partially sampled echoes. Cramer-Rao Lower Bounds (CRLBs) are used as measure of performances. The novel scheme was compared with the traditional Multi-Echo Multi-Shot (MEMS) method. Results confirmed former in-silico studies and indicate that MESS outperforms MEMS for simultaneous determinations of T2s and concentrations, with improvements ranging from 5-20% for T2s and 10-50% for concentrations.
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