Little or no correlation exists between diffusion and T2 relaxation of intracellular brain metabolites, as measured by MRS. However, for lactate, which is both intracellular and extracellular, some correlation might exist, which would be crucial to interpret lactate diffusion. Using a frequency-selective diffusion-weighted (DW) MRS sequence that removes J-modulation on the lactate peak at 1.3 ppm, thus preserving lactate signal even at long TE, we investigated the effect of echo time TE on lactate diffusion-weighted attenuation, for TE between 50.9 and 110.9 ms. It appears that the effect of TE on the apparent diffusivity and kurtosis is negligible.
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