Abstract #0320

Effects of the cardiac and respiratory cycles on CSF-mobility in human subarachnoid and perivascular spaces

Lydiane Hirschler¹, Bobby A Runderkamp², Susanne J van Veluw^1,3, Matthan WA Caan⁴, and Matthias JP van Osch¹

¹Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands, ³Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, ⁴Biomedical Engineering & Physics, Amsterdam University Medical Center, Amsterdam, Netherlands

Synopsis

Although research into brain waste clearance has recently gained increasing attention, the driving force(s) as well as the physiological processes involved still remain strongly debated. Here, we assess the influence of the cardiac cycle and of respiration on the mobility of cerebrospinal fluid (CSF), thought to be an important waste carrier. We found that the cardiac cycle was inducing higher CSF-mobility changes than respiration.

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