Effects of the cardiac and respiratory cycles on CSF-mobility in human subarachnoid and perivascular spaces
Lydiane Hirschler1, Bobby A Runderkamp2, Susanne J van Veluw1,3, Matthan WA Caan4, and Matthias JP van Osch1
1Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands, 3Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 4Biomedical Engineering & Physics, Amsterdam University Medical Center, Amsterdam, Netherlands
Although research into brain waste clearance has recently gained increasing attention, the driving force(s) as well as the physiological processes involved still remain strongly debated. Here, we assess the influence of the cardiac cycle and of respiration on the mobility of cerebrospinal fluid (CSF), thought to be an important waste carrier. We found that the cardiac cycle was inducing higher CSF-mobility changes than respiration.
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