High spatial resolution real-time imaging of respiratory effects on cerebrospinal fluid flow at 7T
Johannes Töger1, Mads Andersen2,3, Olle Haglund4, Tekla Kylkilahti5,6, Iben Lundgaard5,6, and Karin Markenroth Bloch3
1Department of Clinical Sciences, Diagnostic Radiology, Skane University Hospital Lund, Lund University, Lund, Sweden, 2Philips Healthcare, Copenhagen, Denmark, 3Lund University Bioimaging Center, Lund University, Lund, Sweden, 4Department of Medical Radiation Physics, Lund University, Lund, Sweden, 5Department of Experimental Medical Science, Lund University, Lund, Sweden, 6Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden
Methods to quantify CSF flow dynamics are important to study the physiology of intracranial pressure variations. Respiration influences the CSF flow, making real-time acquisitions necessary. This work investigates a high-resolution radial real-time flow sequence with golden angle acquisition and compressed sensing reconstruction at 7T for flow quantification of the CSF flow in the aqueduct. Phantom data shows that the proposed method accurately quantifies the slower aqueduct CSF flow oscillations caused by respiration, but underestimates faster cardiac oscillations. In vivo data shows good repeatability and an association between respiratory condition and net CSF flow.
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