Abstract #0324

Contrast Agent Transport in Mouse Glymphatic System Observed by Dynamic Contrast-Enhanced MRI

Yuran Zhu¹, Yuning Gu¹, Kihwan Kim¹, Chaitanya Kolluru¹, Huiyun Gao², Yunmei Wang^2,3, David L. Wilson^1,4,5, Chris A. Flask^1,4,6,7,8, and Xin Yu^1,4,9

¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Cardiovascular Research Institute, Case Western Reserve University, Cleveland, OH, United States, ³Department of Medicine, Case Western Reserve University, Cleveland, OH, United States, ⁴Department of Radiology, Case Western Reserve University, Cleveland, OH, United States, ⁵Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, United States, ⁶Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States, ⁷Imaging Research Core, Case Western Reserve University, Cleveland, OH, United States, ⁸Cancer Imaging Program, Case Western Reserve University, Cleveland, OH, United States, ⁹Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States

Synopsis

This study compared the transport of three MRI contrast agents with different molecular sizes (Gd-DTPA, GadoSpin, and H₂¹⁷O) in the mouse glymphatic system with dynamic contrast-enhanced MRI. Dynamic signal changes in the whole-brain and selected regions of interest (ROI) were analyzed. The results showed drastically different kinetics of the three tracers, indicating differences in glymphatic transport routes and rates. The current work lays the foundation for future studies employing genetically manipulated mouse models for mechanistic understanding of the regulation of glymphatic function in normal and diseased conditions.

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