Age dependent cerebrospinal fluid-tissue water exchange detected by non-invasive magnetization transfer indirect spin labeling MRI
Anna Li1, Chen Lin1,2, Hongshuai Liu3, Yuguo Li1,4, Wenzhen Duan3, and Jiadi Xu1,4
1F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, 2Department of Electronic Science, Xiamen University, Xiamen, China, 3Division of Neurobiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States
Our understanding of the CSF exchange with surrounding tissues and its correlation with brain function is limited. We presented a non-invasive magnetization transfer indirect spin labeling (MISL) MRI method to quantify the water exchange between cerebrospinal fluid (CSF) and surrounding tissues in the brain by making use of the significantly different protein concentrations between CSF and other tissues. Water in the surrounding tissue is directly labeled by magnetization transfer from the abundant macromolecule pool. The reduction in the CSF signal corresponds to the water traveled to CSF, which is strongly age-dependent and weakly AQP4-dependent.
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