Our understanding of the CSF exchange with surrounding tissues and its correlation with brain function is limited. We presented a non-invasive magnetization transfer indirect spin labeling (MISL) MRI method to quantify the water exchange between cerebrospinal fluid (CSF) and surrounding tissues in the brain by making use of the significantly different protein concentrations between CSF and other tissues. Water in the surrounding tissue is directly labeled by magnetization transfer from the abundant macromolecule pool. The reduction in the CSF signal corresponds to the water traveled to CSF, which is strongly age-dependent and weakly AQP4-dependent.
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