Abstract #0326

On the origin of a potential clearance marker: The contribution of enlarged perivascular fluid diffusion to a 7T IVIM interstitial fluid proxy

Merel M. van der Thiel^1,2, Nathalie A. Roos^1,3, Gerhard S. Drenthen^1,2, Paulien H.M. Voorter^1,2, Thorsten Feiweier⁴, Inez H.G.B. Ramakers^2,5, Walter H. Backes^1,2,6, and Jacobus F.A. Jansen^1,2,7

¹Department of Radiology & Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, ²School for Mental Health & Neuroscience, Maastricht University, Maastricht, Netherlands, ³Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, ⁴Siemens Healthcare, Erlangen, Germany, ⁵Department of Psychiatry & Neuropsychology, Maastricht University, Maastricht, Netherlands, ⁶School for Cardiovascular Disease, Maastricht University, Maastricht, Netherlands, ⁷Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

Synopsis

Between the parenchymal and microvascular diffusion components, a third, intermediate component can be derived with cerebral IVIM. Its fraction (f_int) seems a promising biomarker for altered cerebral clearance function. f_int has been suggested to both be driven by fluid diffusivity within enlarged perivascular spaces (ePVS) and interstitial fluid between parenchymal cells. Using 7T MRI, this study determined a higher f_int within the ePVS (through segmented masks) compared to surrounding non-ePVS tissue. Thereby, this study illustrates the contribution of ePVS fluid diffusivity to f_int and highlights the ability to specifically assess ePVS fluid diffusion using a non-invasive MRI method.

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