On the origin of a potential clearance marker: The contribution of enlarged perivascular fluid diffusion to a 7T IVIM interstitial fluid proxy
Merel M. van der Thiel1,2, Nathalie A. Roos1,3, Gerhard S. Drenthen1,2, Paulien H.M. Voorter1,2, Thorsten Feiweier4, Inez H.G.B. Ramakers2,5, Walter H. Backes1,2,6, and Jacobus F.A. Jansen1,2,7
1Department of Radiology & Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, 2School for Mental Health & Neuroscience, Maastricht University, Maastricht, Netherlands, 3Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 4Siemens Healthcare, Erlangen, Germany, 5Department of Psychiatry & Neuropsychology, Maastricht University, Maastricht, Netherlands, 6School for Cardiovascular Disease, Maastricht University, Maastricht, Netherlands, 7Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands
Between the parenchymal and microvascular diffusion components, a third, intermediate component can be derived with cerebral IVIM. Its fraction (fint) seems a promising biomarker for altered cerebral clearance function. fint has been suggested to both be driven by fluid diffusivity within enlarged perivascular spaces (ePVS) and interstitial fluid between parenchymal cells. Using 7T MRI, this study determined a higher fint within the ePVS (through segmented masks) compared to surrounding non-ePVS tissue. Thereby, this study illustrates the contribution of ePVS fluid diffusivity to fint and highlights the ability to specifically assess ePVS fluid diffusion using a non-invasive MRI method.
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