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Abstract #0327

Quantitative imaging of brain to cerebrospinal fluid molecular clearance

Anders Wåhlin1,2,3, Anders Garpebring3, Klara Mogensen3, Tomas Vikner3, Cecilia Björnfot3, Sara Qvarlander3, Jan Malm4, and Anders Eklund2,3
1Department of Applied Physics and Electronics, Umeå University, Umeå, Sweden, 2Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden, 3Department of Radiation Sciences, Umeå University, Umeå, Sweden, 4Department of Clinical Science, Umeå University, Umeå, Sweden


The pathways of brain molecular clearance and potential glymphatic efflux to extracerebral cerebrospinal fluid is a matter of intense research. We investigated possible contrast enrichment in cerebrospinal fluid of the subarachnoid space following intravenous contrast injection. This approach utilizes a subtle but widespread contrast leakage across the blood-brain barrier that potentially enables the investigation of glymphatic function. Using T1-mapping as well as dynamic scanning during contrast infusion, we present data consistent with a model where molecules cleared from the brain enter subarachnoid space cerebrospinal fluid. This approach could be a clinically feasible alternative for investigating brain molecular clearance in humans.

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