The pathways of brain molecular clearance and potential glymphatic efflux to extracerebral cerebrospinal fluid is a matter of intense research. We investigated possible contrast enrichment in cerebrospinal fluid of the subarachnoid space following intravenous contrast injection. This approach utilizes a subtle but widespread contrast leakage across the blood-brain barrier that potentially enables the investigation of glymphatic function. Using T1-mapping as well as dynamic scanning during contrast infusion, we present data consistent with a model where molecules cleared from the brain enter subarachnoid space cerebrospinal fluid. This approach could be a clinically feasible alternative for investigating brain molecular clearance in humans.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords