Feasibility of simultaneous non-contrast coronary MR angiography and vulnerable plaque imaging in acute myocardial infarction
Reza Hajhosseiny1,2, Adam Hartley2, Graham Cole2, Camila Munoz1, Amarjit Sethi2, Rasha Al-Lamee2, Deepa Gopalan2, Ben Ariff2, Raffi Kaprielian2, Karl Kunze3,4, Radhouene Neji3,4, Claudia Prieto1, Ramzi Khamis2, and René M Botnar1
1Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2National Heart and Lung Institute, Imperial College London, London, United Kingdom, 3MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom, 4School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom
CMR plaque imaging has the potential to predict future coronary events, but is limited by low spatial-resolution, misregistration artefacts, respiratory motion related image quality degradation and unpredictable acquisition times. Here we clinically evaluate the feasibility of a novel 3D free-breathing, non-rigid motion corrected, non-contrast CMR sequence (iT2prep-BOOST) that enables simultaneous, high-resolution visualisation of the coronary arteries and high-risk plaque features on co-registered bright and black blood images in patients presenting with acute myocardial infarction. We found that iT2prep-BOOST can simultaneously visualise coronary artery stenosis as well as culprit and bystander coronary plaque, as validated against invasive coronary angiography and OCT.
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