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Abstract #0343

T1ρ can detect microstructural changes in cartilage induced by conservative interventions: a one-year randomized controlled trial

Valentina Mazzoli1,2, Scott Uhlrich2,3, Feliks Kogan1, Amy Silder2,4, Andrea Finlay5, Scott Delp 3,4, Gary Beaupre4,6, Julie Kolesar4,6, and Garry Gold1
1Radiology, Stanford University, Stanford, CA, United States, 2Musculoskeletal Research Laboratory, VA Palo Alto Healthcare System, Palo Alto, CA, United States, 3Mechanical Engineering, Stanford University, Stanford, CA, United States, 4Bioengineering, Stanford University, Stanford, CA, United States, 5Center for Innovation and Implementation, VA Palo Alto Healtcare System, Palo Alto, CA, United States, 6Musculoskeletal Research Laboratory, VA Palo Alto Healtcare System, Palo Alto, CA, United States

Synopsis

We performed a single-blind randomized clinical trial in subjects with medial knee OA to evaluate the effect of a gait modification. Primary outcomes were pain and KAM (surrogate measure of medial knee loading). We also utilized cartilage T2 and T1ρ to assess (micro)structural changes induced by the treatment. In the Intervention group, we observed a greater reduction in pain and KAM (reduced loading), and less increase in T1ρ in the medial femoral compartment, potentially indicating slowed cartilage degeneration. Our study shows that quantitative cartilage MRI is a promising outcome measure in clinical trial assessing non-surgical treatment for knee OA.

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