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Abstract #0342

The Knee Connectome: Studying Localized Synchrony in 8-year Cartilage Changes in Thickness and T2

Jennifer Anne Cummings1, Kenneth Gao1, Vincent Chen2, Alejandro Morales Martinez2, Sharmila Majumdar1, and Valentina Pedoia1
1University of California, San Francisco, San Francsico, CA, United States, 2University of California, San Francisco, San Francisco, CA, United States


The trajectories of femur cartilage thickness and T2 relaxation time over an 8 year period were analyzed for 787 subjects from the Osteoarthritis Initiative dataset. Biomarkers were automatically extracted and used to generate time series for 27 regions of interest within the cartilage map to create a connectivity matrix (connectome). Statistically significant differences in thickness and T2 trajectories were found to correlate with demographic and clinical factors such as sex, BMI, Radiographic OA and presence of knee pain.

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