The trajectories of femur cartilage thickness and T2 relaxation time over an 8 year period were analyzed for 787 subjects from the Osteoarthritis Initiative dataset. Biomarkers were automatically extracted and used to generate time series for 27 regions of interest within the cartilage map to create a connectivity matrix (connectome). Statistically significant differences in thickness and T2 trajectories were found to correlate with demographic and clinical factors such as sex, BMI, Radiographic OA and presence of knee pain.
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