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Abstract #0347

Bi-exponential UTE-T2* Evaluation of Longitudinal Changes in Knee Cartilage Over 2 Years Following Anterior Cruciate Ligament Reconstruction

Ashley A Williams1,2, Yongxian Qian3,4, and Constance R Chu1,2
1Orthopaedic Surgery, Stanford University, Stanford, CA, United States, 2Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States, 3Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 4Center for Biomedical Imaging, NYU Langone Health, New York, NY, United States


This work evaluates mono- and bi-exponential UTE-T2* relaxation in 6 tread mark regions of knee cartilage of 18 participants with ACL-injury prior to reconstruction surgery and in 15/18 participants 2 years after surgery. Bi-exponential T2*short had a smaller fractional contribution than T2*long in all regions examined. However, T2*short accounted for a higher fraction of total signal in deep cartilage layers compared to superficial. While both mono- and bi-exponential UTE-T2* analyses showed significant longitudinal changes, bi-exponential analyses did not exceed the sensitivity of mono-exponential UTE-T2* for detection of knee cartilage compositional changes over the first two years following ACL reconstruction.

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