Abstract #0347

**Bi-exponential UTE-T2* Evaluation of Longitudinal Changes in Knee Cartilage Over 2 Years Following Anterior Cruciate Ligament Reconstruction**

Ashley A Williams^1,2, Yongxian Qian^3,4, and Constance R Chu^1,2

¹Orthopaedic Surgery, Stanford University, Stanford, CA, United States, ²Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States, ³Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ⁴Center for Biomedical Imaging, NYU Langone Health, New York, NY, United States

Synopsis

This work evaluates mono- and bi-exponential UTE-T2* relaxation in 6 tread mark regions of knee cartilage of 18 participants with ACL-injury prior to reconstruction surgery and in 15/18 participants 2 years after surgery. Bi-exponential T2*_shorthad a smaller fractional contribution than T2*_long in all regions examined. However, T2*_short accounted for a higher fraction of total signal in deep cartilage layers compared to superficial. While both mono- and bi-exponential UTE-T2* analyses showed significant longitudinal changes, bi-exponential analyses did not exceed the sensitivity of mono-exponential UTE-T2* for detection of knee cartilage compositional changes over the first two years following ACL reconstruction.

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