In this exploratory study, we examine relationships between joint function and cartilage composition in individuals with knee osteoarthritis (OA). MRI T2 relaxation times were used to assess articular cartilage and joint kinematics were recorded over walking gait cycles using video-motion analysis. There were significant correlations between cartilage T2 relaxation times and knee flexion, extension, and swing-stance ratio in both affected and contralateral legs. MRI measures of cartilage quality and joint function provide complimentary information that may be useful in measuring disease progression and intervention effectiveness using MRI.
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