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Abstract #0361

The impact and correction of inter-scan motion artefacts in variable flip angle R1 mapping at 3T and 7T

Martina F Callaghan1, Ali Aghaeifar1,2, Yael Balbastre1,3, and Nadège Corbin1,4
1Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom, 3Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, 4Centre de Résonance Magnétique des Systèmes Biologiques, CNRS/University Bordeaux, Bordeaux, France


Images acquired with variable nominal flip angle (VFA) can be combined with a map of the transmit field efficiency and a signal model to estimate the longitudinal relaxation rate, R1. However, if motion occurs between the acquisition of the VFA volumes the inherent assumptions of consistent receive field modulation and transmit field efficiency can be violated causing substantial errors in R1. Through in vivo experiment and simulation we show that the differential receive field modulation introduces the largest amount of error. We further show that the majority of the error can be mitigated with a simple, time efficient correction.

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