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Abstract #0362

Shuttered Echo Planar fMRI with Dynamic Motion and Phase Correction

Saikat Sengupta1,2, Jonathan R Polimeni3,4,5, Kawin Setsompop6, and William A Grissom1,7
1Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 2Department of Radiology, Vanderbilt University Medical Center, Nashville, TN, United States, 3Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 4Department of Radiology, Harvard Medical School, Boston, MA, United States, 5Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States, 6Radiological Sciences Laboratory, Stanford University, Standford, CA, United States, 7Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States


Achieving submillimeter-resolution BOLD fMRI is a challenge since single-shot EPI suffers from long echo times, blurring, and image distortions, while multishot EPI suffers from motion- and respiration-induced shot-to-shot phase errors. In shuttered multishot EPI, data are acquired in each shot after exciting a set of interleaved “shutters” across the imaged slice. This enables high quality reconstructions from each shot, which in turn enables navigator-free shot-wise phase and motion corrections prior to reconstructing a full-FOV image. Herein we describe a full motion- and phase-correcting image reconstruction for dynamic shuttered EPI and validate it in head motion and BOLD fMRI experiments.

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