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Abstract #0368

Microscopic neuropathology can be seen using accelerated combined diffusion-relaxation MRI

Dan Benjamini1, Mustapha Bouhrara1, Michal E Komlosh2, Diego Iacono3, Daniel P Perl3, David L Brody3, and Peter J Basser2
1National Institute on Aging, Baltimore, MD, United States, 2National Institute of Child Health and Human Development, Bethesda, MD, United States, 3Uniformed Services University of the Health Sciences, Bethesda, MD, United States


Here we present MRI acquisitions that maximize the amount of information in an image by using a combination of magnetic field profiles to probe relaxation and diffusion mechanisms simultaneously, thus resolving sub-voxel information from ex vivo brain segments of human subjects that sustained traumatic brain injury. We then propose a strategy to refine the ensuing abundance of high-dimensional data, and to sort and recover biologically relevant information into actionable and quantitative injury biomarker images that capture subtle neuropathology.

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