Abstract #0368

Microscopic neuropathology can be seen using accelerated combined diffusion-relaxation MRI

Dan Benjamini¹, Mustapha Bouhrara¹, Michal E Komlosh², Diego Iacono³, Daniel P Perl³, David L Brody³, and Peter J Basser²

¹National Institute on Aging, Baltimore, MD, United States, ²National Institute of Child Health and Human Development, Bethesda, MD, United States, ³Uniformed Services University of the Health Sciences, Bethesda, MD, United States

Synopsis

Here we present MRI acquisitions that maximize the amount of information in an image by using a combination of magnetic field profiles to probe relaxation and diffusion mechanisms simultaneously, thus resolving sub-voxel information from ex vivo brain segments of human subjects that sustained traumatic brain injury. We then propose a strategy to refine the ensuing abundance of high-dimensional data, and to sort and recover biologically relevant information into actionable and quantitative injury biomarker images that capture subtle neuropathology.

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