Quantitative atlas of T1 relaxation times in the cerebral cortex for personalized characterization of pathology
Gian Franco Piredda1,2,3, Marion Claudet1, Tom Hilbert1,2,3, Manuela Vaneckova4, Jan Krasensky4, Michaela Andelova5, Tomas Uher5, Eva Kubala Havrdova5, Karolina Vodehnalova5, Dana Horakova5, Karl Egger6, Shan Yang6, Riccardo Ludovichetti7, Lindsey A. Crowe7, Bénédicte M. A. Delattre7, Maria Isabel Vargas7, Veronica Ravano1,2,3, Bénédicte Maréchal1,2,3, Jean-Philippe Thiran2,3, and Tobias Kober1,2,3
1Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 2Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 3LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 4Department of Radiology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic, 5Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic, 6Department of Neuroradiology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 7Divsion of Neuroradiology, Department of Radiology and Medical Informatics, Hôpitaux Universitaires de Genève (HUG), Geneva, Switzerland
Comparing single-patient data to atlases of normative relaxation times in the brain enables personalized characterization of pathological tissue. However, an accurate comparison is challenging in the cortex due to the gyrification of gray matter and resulting registration problems. This work addresses this problem for parametric T1 maps that were acquired from 285 healthy subjects. A method aligning inter-subject brain cortices was developed to enable the comparison of cortical T1 values. We thus established a normative atlas accounting for healthy T1 values in brain cortical tissues, to be used to detect and characterize pathology-induced T1 alterations in patients.
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