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Abstract #0374

MR-Thermometry based targeting for histotripsy treatments in ex-vivo tissues

Dinank Gupta1, Dave Choi1, Steven Allen2, Tim Hall1, Zhen Xu1, and Douglas Noll1
1University of Michigan, Ann Arbor, MI, United States, 2Brigham Young University, Provo, UT, United States


The accuracy of using MR-Thermometry for pre-treatment targeting for histotripsy was evaluated on ex-vivo tissues. Eight brain samples were treated with an ultrasound array capable of performing both heating and histotripsy treatments. Heating was performed at array focus while MR-Thermometry images were acquired. Subsequently, histotripsy lesions were also made at the focus and post-treatment images were acquired. The location of MR-Thermometry estimated focal-zone was compared with the observed histotripsy lesion location to assess the accuracy of MR-Thermometry targeting. The mean error in estimated focus was about 1mm in all axes, suggesting MR-Thermometry would be suitable for pre-treatment targeting for histotripsy.

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