The accuracy of using MR-Thermometry for pre-treatment targeting for histotripsy was evaluated on ex-vivo tissues. Eight brain samples were treated with an ultrasound array capable of performing both heating and histotripsy treatments. Heating was performed at array focus while MR-Thermometry images were acquired. Subsequently, histotripsy lesions were also made at the focus and post-treatment images were acquired. The location of MR-Thermometry estimated focal-zone was compared with the observed histotripsy lesion location to assess the accuracy of MR-Thermometry targeting. The mean error in estimated focus was about 1mm in all axes, suggesting MR-Thermometry would be suitable for pre-treatment targeting for histotripsy.
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